Tesamorelin (10mg) (20mg)

A single-component research material supplied for controlled research environments. Suitable for studies involving GHRH-receptor pathway characterization and method development in model systems.

Composition

• Tesamorelin
• Appearance: Lyophilized powder in a sealed research vial

Research Focus (non-clinical)

• Identity and purity assessment via HPLC/LC-MS
• Assay development for GHRH receptor models (e.g., binding and cell-based workflows)
• Chromatographic method optimization for variant and impurity profiling
• Stability characterization of a lyophilized peptide under laboratory storage conditions

For qualified research professionals and institutional laboratories. Not for human use.

Documentation & Quality Assurance

Each lot is sourced through our verified global supply chain with emphasis on traceability and quality control. We work diligently to obtain and maintain third-party analytical reports (HPLC/LC-MS) and Certificates of Analysis for each batch, as part of our ongoing quality process. These documents are reviewed internally and displayed as they become available. Independent third-party testing is also performed on select lots to confirm identity, purity, and alignment with our internal specifications.

Important Notice

This product is intended for laboratory research use only. It is not intended for human or veterinary use, and must not be used for diagnostic, therapeutic, or clinical purposes.
This material is not a drug, medical device, or dietary supplement, and has not been evaluated by the U.S. Food and Drug Administration.

Quality & Manufacturing

All materials are sourced from carefully vetted domestic and international manufacturing partners who follow quality systems consistent with ISO and cGMP principles. Each supplier is reviewed for reliability, documentation integrity, and transparency in testing.

We require a verified purity of 99% or higher and perform independent third-party spot testing to confirm that select lots meet our internal standards for identity, purity, and composition. Where available, endotoxin testing results are included on Certificates of Analysis to verify laboratory purity; their inclusion is for research quality assessment only and does not imply suitability for human or veterinary use.

All research materials are sealed for integrity and packaged for stability during storage and transport from manufacturing through final delivery.

What It Is

Tesamorelin is a synthetic 44-amino-acid polypeptide analogue of human growth-hormone-releasing hormone (GHRH) in which a trans-3-hexenoic acid (hexenoyl) moiety is covalently attached to the tyrosine residue at the amino terminus, a modification associated with resistance to proteolytic degradation by the serum enzyme dipeptidylaminopeptidase 4 (DPP-4) relative to native GHRH.

Research Background

Preclinical investigations reported that the hexenoyl modification renders tesamorelin resistant to deactivation by DPP-4 and was associated with increased plasma GH and IGF-1 levels in preclinical models. Subsequent clinical research has included randomized, placebo-controlled Phase III trials enrolling several hundred participants, as well as 52-week safety extension studies, pooled analyses across multiple trials, and a 12-week randomized placebo-controlled study in participants with type 2 diabetes. A separate study in thirteen healthy male volunteers examined the compound's effects on endogenous GH pulsatility and insulin sensitivity over a two-week administration period followed by a washout phase.

Observed Areas of Interest in Research

Researchers have studied tesamorelin's binding to and activation of pituitary GHRH receptors, described as leading to synthesis and release of growth hormone by pituitary cells. Within the GH/IGF-1 axis, investigators have examined downstream hepatic production of insulin-like growth factor-1 (IGF-1) and IGF-1-mediated signaling, including its reported roles in glucose uptake and lipolysis. Studies have also characterized the pulsatile pattern of GH secretion elicited by the compound — as distinct from continuous exogenous GH delivery — noting, as a mechanistic expectation, that GHRH-receptor stimulation would preserve hypothalamic-pituitary feedback inhibition via IGF-1. A study in healthy male subjects measured augmentation of mean overnight GH, GH peak area, and basal GH secretion alongside a mean IGF-1 increase of approximately 181 µg/L, while monitoring insulin-stimulated glucose uptake as a secondary pathway of interest.

Research Notes

Purity verified by third-party laboratory analysis (Certificate of Analysis available on request). Supplied strictly for in-vitro and laboratory research use only. Not for human consumption.

All information above is provided for research and educational reference only and summarizes findings from published scientific literature (predominantly in-vitro and animal models). It does not describe outcomes in humans. This product is not a drug, dietary supplement, or article intended for human or veterinary use.

All products from Blitz Health are manufactured using a lyophilization (freeze-drying) process. This method is designed to maintain product integrity and allows vials to remain stable during shipping for approximately 3–4 months.

Once a vial is reconstituted with bacteriostatic water, it should be stored in the refrigerator to help maintain stability. Under these conditions, reconstituted material is generally considered stable for up to 30 days.

Lyophilization is a dehydration technique in which compounds are frozen and then exposed to low pressure. This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure. This powder can be kept at room temperature until reconstitution.

Upon receipt, products should be stored away from heat and light. For short-term use, refrigeration at approximately 4°C (39°F) is suitable. For long-term storage (several months to years), vials may be placed in a freezer at approximately -80°C (-112°F). Freezing is the preferred method for preserving product stability over extended periods.

⚠️ Important Notice:
These products are intended for research use only. Not for human consumption.