SLU-PP-332 (5mg)

A single-component research material supplied for controlled research environments. Formulated for advanced studies examining metabolic regulation, mitochondrial activity, and peptide signaling pathways in model systems.

Composition

• SLU-PP-332
• Appearance: Lyophilized powder in a sealed research vial

Research Focus (non-clinical)

• Evaluation of peptide impact on PGC-1α signaling and mitochondrial biogenesis
• Studies investigating potential roles in skeletal muscle metabolism models
• Development of in-vitro and in-vivo assays for metabolic pathway mapping
• Stability and solubility testing of SLU-PP-332 under various laboratory conditions

For qualified research professionals and institutional laboratories. Not for human use.

Documentation & Quality Assurance

Each lot is sourced through our verified global supply chain with emphasis on traceability and quality control. We work diligently to obtain and maintain third-party analytical reports (HPLC/LC-MS) and Certificates of Analysis for each batch, as part of our ongoing quality process. These documents are reviewed internally and displayed as they become available. Independent third-party testing is also performed on select lots to confirm identity, purity, and alignment with our internal specifications.

Important Notice

This product is intended for laboratory research use only. It is not intended for human or veterinary use, and must not be used for diagnostic, therapeutic, or clinical purposes.
This material is not a drug, medical device, or dietary supplement, and has not been evaluated by the U.S. Food and Drug Administration.

Quality & Manufacturing

All materials are sourced from carefully vetted domestic and international manufacturing partners who follow quality systems consistent with ISO and cGMP principles. Each supplier is reviewed for reliability, documentation integrity, and transparency in testing.

We require a verified purity of 99% or higher and perform independent third-party spot testing to confirm that select lots meet our internal standards for identity, purity, and composition. Where available, endotoxin testing results are included on Certificates of Analysis to verify laboratory purity; their inclusion is for research quality assessment only and does not imply suitability for human or veterinary use.

All research materials are sealed for integrity and packaged for stability during storage and transport from manufacturing through final delivery.

What It Is

SLU-PP-332 is a synthetic small-molecule N-acylhydrazone compound rationally designed as a pan-agonist of all three estrogen-related receptor (ERR) isoforms — ERRα, ERRβ, and ERRγ — members of the nuclear receptor superfamily.

Research Background

SLU-PP-332 was developed from the GSK4716 scaffold, with structural modifications — including substitution of a naphthalene-2-yl moiety — intended to enhance hydrophobic interactions with the ERR ligand-binding domain, as characterized in HEK293 cell reporter assays and C2C12 skeletal muscle myotube models. In vivo investigations have been conducted in normal chow-fed C57BL/6 mice, diet-induced obesity models, and genetically obese ob/ob mice receiving intraperitoneal administration. A separate aging-focused study examined the compound in 21-month-old mice over an 8-week treatment period, alongside in vitro work in primary human proximal tubule epithelial cells and histological analysis of archived human kidney tissue sections. No interventional clinical trials involving SLU-PP-332 in human subjects have been reported in the peer-reviewed sources examined.

Observed Areas of Interest in Research

Researchers have characterized SLU-PP-332 as activating ERRα, ERRβ, and ERRγ in cell-based assays, with reported EC50 values of approximately 0.22 µM at ERRα and 0.59 µM at ERRγ in luciferase reporter systems. Transcriptional profiling in cellular models has identified downstream modulation of canonical ERR target genes — including PDK4, PGC-1α, CPT1α — and pathway enrichment in oxidative phosphorylation, the TCA cycle, and fatty acid degradation, consistent with what investigators have characterized as a mitochondrial exercise-mimetic transcriptional program. In animal models, researchers have also studied the compound's relationship to mitochondrial biogenesis markers (mitochondrial DNA/nuclear DNA ratio, PGC-1α/β expression) and inflammatory signaling nodes including cGAS-STING and STAT3 pathways. Structure-activity relationship analyses have reported that the hydrazone carbonyl is indispensable for receptor activation and that the aromatic ring architecture is a determinant of ERR isoform potency across the compound class.

Research Notes

Purity verified by third-party laboratory analysis (Certificate of Analysis available on request). Supplied strictly for in-vitro and laboratory research use only. Not for human consumption.

All information above is provided for research and educational reference only and summarizes findings from published scientific literature (predominantly in-vitro and animal models). It does not describe outcomes in humans. This product is not a drug, dietary supplement, or article intended for human or veterinary use.

All products from Blitz Health are manufactured using a lyophilization (freeze-drying) process. This method is designed to maintain product integrity and allows vials to remain stable during shipping for approximately 3–4 months.

Once a vial is reconstituted with bacteriostatic water, it should be stored in the refrigerator to help maintain stability. Under these conditions, reconstituted material is generally considered stable for up to 30 days.

Lyophilization is a dehydration technique in which compounds are frozen and then exposed to low pressure. This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure. This powder can be kept at room temperature until reconstitution.

Upon receipt, products should be stored away from heat and light. For short-term use, refrigeration at approximately 4°C (39°F) is suitable. For long-term storage (several months to years), vials may be placed in a freezer at approximately -80°C (-112°F). Freezing is the preferred method for preserving product stability over extended periods.

⚠️ Important Notice:
These products are intended for research use only. Not for human consumption.