GHK-Cu

A single-component research material supplied for controlled research environments. Suitable for studies involving peptide characterization and method development in model systems.

Composition

• GHK-Cu
• Appearance: Lyophilized powder in a sealed research vial

Research Focus (non-clinical)

• Peptide identity and purity assessment via HPLC/LC-MS
• Assay development and calibration for quantitative analysis
• Chromatographic method optimization for impurity profiling
• Stability characterization of a lyophilized peptide under laboratory storage conditions

For qualified research professionals and institutional laboratories. Not for human use.

Documentation & Quality Assurance

Each lot is sourced through our verified global supply chain with emphasis on traceability and quality control. We work diligently to obtain and maintain third-party analytical reports (HPLC/LC-MS) and Certificates of Analysis for each batch, as part of our ongoing quality process. These documents are reviewed internally and displayed as they become available. Independent third-party testing is also performed on select lots to confirm identity, purity, and alignment with our internal specifications.

Important Notice

This product is intended for laboratory research use only. It is not intended for human or veterinary use, and must not be used for diagnostic, therapeutic, or clinical purposes.
This material is not a drug, medical device, or dietary supplement, and has not been evaluated by the U.S. Food and Drug Administration.

Quality & Manufacturing

All materials are sourced from carefully vetted domestic and international manufacturing partners who follow quality systems consistent with ISO and cGMP principles. Each supplier is reviewed for reliability, documentation integrity, and transparency in testing.

We require a verified purity of 99% or higher and perform independent third-party spot testing to confirm that select lots meet our internal standards for identity, purity, and composition. Where available, endotoxin testing results are included on Certificates of Analysis to verify laboratory purity; their inclusion is for research quality assessment only and does not imply suitability for human or veterinary use.

All research materials are sealed for integrity and packaged for stability during storage and transport from manufacturing through final delivery.

What It Is

GHK-Cu is a copper(II) coordination complex of the human tripeptide glycyl-L-histidyl-L-lysine, in which the Cu(II) ion is coordinated by the imidazole side-chain nitrogen of histidine, the alpha-amino nitrogen of glycine, and the deprotonated amide nitrogen of the peptide bond, conferring a copper(II) affinity comparable to the copper-transport site on albumin.

Research Background

GHK-Cu has been investigated across a range of in vitro systems, including cultured human dermal fibroblasts, lung fibroblasts derived from COPD patients, keratinocyte-containing skin equivalents, mesenchymal stromal cells, and several human cancer cell lines. In vivo studies have employed subcutaneous wound-chamber implant models in rats, as well as wound-healing paradigms in rabbits, mice, pigs, and dogs. A limited number of placebo-controlled clinical studies in human subjects have also been conducted, including trials examining skin biopsy endpoints via immunohistological analysis. Additionally, genome-wide gene-expression profiling has been applied to characterize the compound's influence on large-scale transcriptional programs across multiple tissue types.

Observed Areas of Interest in Research

Research has examined GHK-Cu's modulation of extracellular matrix metabolism, specifically its capacity to influence synthesis and breakdown of collagen (types I and III) and glycosaminoglycans, as well as the activity of matrix metalloproteinases and their inhibitors TIMP-1 and TIMP-2; in a rat in vivo wound-chamber model, type I and type III collagen mRNAs were found to be elevated while TGF-beta mRNAs were not, suggesting pathway-specific transcriptional effects independent of that growth factor. Investigators have also studied the compound's interaction with integrin signaling, including upregulation of integrin beta-1 expression and elevation of epidermal stem-cell markers such as p63 in basal keratinocytes. Genome-profiling analyses reported in published reviews identified putative regulation of genes associated with DNA repair, NF-kB suppression, proteasome pathway activation, and reversal of transcriptional signatures associated with emphysema and certain cancer cell line models. Anti-inflammatory mechanisms studied include suppression of TNF-alpha-induced IL-6 secretion in dermal fibroblasts.

Research Notes

Purity verified by third-party laboratory analysis (Certificate of Analysis available on request). Supplied strictly for in-vitro and laboratory research use only. Not for human consumption.

All information above is provided for research and educational reference only and summarizes findings from published scientific literature (predominantly in-vitro and animal models). It does not describe outcomes in humans. This product is not a drug, dietary supplement, or article intended for human or veterinary use.

All products from Blitz Health are manufactured using a lyophilization (freeze-drying) process. This method is designed to maintain product integrity and allows vials to remain stable during shipping for approximately 3–4 months.

Once a vial is reconstituted with bacteriostatic water, it should be stored in the refrigerator to help maintain stability. Under these conditions, reconstituted material is generally considered stable for up to 30 days.

Lyophilization is a dehydration technique in which compounds are frozen and then exposed to low pressure. This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure. This powder can be kept at room temperature until reconstitution.

Upon receipt, products should be stored away from heat and light. For short-term use, refrigeration at approximately 4°C (39°F) is suitable. For long-term storage (several months to years), vials may be placed in a freezer at approximately -80°C (-112°F). Freezing is the preferred method for preserving product stability over extended periods.

⚠️ Important Notice:
These products are intended for research use only. Not for human consumption.