Epitalon

A single-component research material supplied for controlled research environments. Suitable for studies involving peptide characterization and method development in model systems.

Composition

• Epitalon
• Appearance: Lyophilized powder in a sealed research vial

Research Focus (non-clinical)

• Peptide identity and purity assessment via HPLC/LC-MS
• Assay development and calibration for quantitative analysis
• Chromatographic method optimization for impurity profiling and peak resolution
• Stability characterization of a lyophilized peptide under laboratory storage conditions

For qualified research professionals and institutional laboratories. Not for human use.

Documentation & Quality Assurance

Each lot is sourced through our verified global supply chain with emphasis on traceability and quality control. We work diligently to obtain and maintain third-party analytical reports (HPLC/LC-MS) and Certificates of Analysis for each batch, as part of our ongoing quality process. These documents are reviewed internally and displayed as they become available. Independent third-party testing is also performed on select lots to confirm identity, purity, and alignment with our internal specifications.

Important Notice

This product is intended for laboratory research use only. It is not intended for human or veterinary use, and must not be used for diagnostic, therapeutic, or clinical purposes.
This material is not a drug, medical device, or dietary supplement, and has not been evaluated by the U.S. Food and Drug Administration.

Quality & Manufacturing

All materials are sourced from carefully vetted domestic and international manufacturing partners who follow quality systems consistent with ISO and cGMP principles. Each supplier is reviewed for reliability, documentation integrity, and transparency in testing.

We require a verified purity of 99% or higher and perform independent third-party spot testing to confirm that select lots meet our internal standards for identity, purity, and composition. Where available, endotoxin testing results are included on Certificates of Analysis to verify laboratory purity; their inclusion is for research quality assessment only and does not imply suitability for human or veterinary use.

All research materials are sealed for integrity and packaged for stability during storage and transport from manufacturing through final delivery.

What It Is

Epitalon (AEDG) is a synthetic tetrapeptide comprising the sequence Ala-Glu-Asp-Gly, joined through α-peptide bonds, originally derived from the amino acid composition of Epithalamin, a bovine pineal gland extract, and subsequently detected in physiological pineal gland tissue.

Research Background

Over approximately 25 years, Epitalon has been examined across in vitro, in vivo, and in silico experimental frameworks. In vitro studies have employed a broad range of cell types including human fetal fibroblasts, HeLa cells, lymphocytes, thymocytes, neuroblastoma cells, pinealocytes, oocytes, and mesenchymal stem cells. Animal models have encompassed multiple rodent strains (Wistar and Sprague-Dawley rats; CBA, SHR, and HER-2/neu transgenic mice), Drosophila melanogaster, Rhesus monkeys, and Xenopus laevis, among others. A limited number of clinical investigations have also been conducted, including a study of 162 patients with retinitis pigmentosa and a study of 75 women examining circadian-related endpoints.

Observed Areas of Interest in Research

Researchers have studied Epitalon in relation to telomere biology, specifically examining whether the compound can induce expression of the catalytic subunit of telomerase (hTERT), modulate enzymatic telomerase activity, and produce measurable telomere elongation in somatic cell cultures. Investigators have also examined the compound's interactions with oxidative-stress pathways, including effects on reactive oxygen species levels, lipid peroxidation, and superoxide dismutase activity in experimental models. Additional research has focused on circadian and neuroendocrine mechanisms, including the modulation of melatonin synthesis in pinealocytes and the expression of circadian clock genes (Clock, Cry2) in animal models. At the molecular level, studies have investigated possible epigenetic mechanisms, including the compound's binding to CAG DNA sequences susceptible to cytosine methylation and its interaction with histone proteins H1/3 and H1/6, as well as its influence on neurogenic gene expression (Nestin, GAP43, β-Tubulin III, Doublecortin) in human mesenchymal stem cell cultures.

Research Notes

Purity verified by third-party laboratory analysis (Certificate of Analysis available on request). Supplied strictly for in-vitro and laboratory research use only. Not for human consumption.

All information above is provided for research and educational reference only and summarizes findings from published scientific literature (predominantly in-vitro and animal models). It does not describe outcomes in humans. This product is not a drug, dietary supplement, or article intended for human or veterinary use.

All products from Blitz Health are manufactured using a lyophilization (freeze-drying) process. This method is designed to maintain product integrity and allows vials to remain stable during shipping for approximately 3–4 months.

Once a vial is reconstituted with bacteriostatic water, it should be stored in the refrigerator to help maintain stability. Under these conditions, reconstituted material is generally considered stable for up to 30 days.

Lyophilization is a dehydration technique in which compounds are frozen and then exposed to low pressure. This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure. This powder can be kept at room temperature until reconstitution.

Upon receipt, products should be stored away from heat and light. For short-term use, refrigeration at approximately 4°C (39°F) is suitable. For long-term storage (several months to years), vials may be placed in a freezer at approximately -80°C (-112°F). Freezing is the preferred method for preserving product stability over extended periods.

⚠️ Important Notice:
These products are intended for research use only. Not for human consumption.