Sleep Stack
The Sleep Stack groups DSIP and Epitalon, two peptides whose research converges on the pineal gland and melatonin regulation.
Why these compounds are studied together
Both compounds are studied within pineal- and melatonin-related research. Delta sleep-inducing peptide (DSIP) has been investigated as a candidate sleep-modulating factor and shown, in animal models, to influence pineal N-acetyltransferase — a key enzyme in melatonin synthesis — along with circadian-rhythm parameters. Epitalon, derived from the pineal peptide epithalamin, has been studied for its effects on the pineal–melatonin axis and circadian regulation. Their shared focus on pineal and melatonin biology is why the two are examined within the same sleep- and circadian-research literature.
Individual research backgrounds
DSIP
Delta sleep-inducing peptide (DSIP) is a nonapeptide (molecular weight 849 Da) originally isolated from rabbit cerebral venous blood and classified as a multifunctional regulatory peptide whose primary structure is distinct from other known peptide families.
DSIP was first isolated in 1977 and has been examined across a range of animal models — including rabbits, rats, mice, and cats — as well as in limited early-phase human studies. Radioimmunochemical and immunohistochemical studies have mapped the distribution of DSIP-like immunoreactive material in brain tissue and peripheral organs across mammalian species. A 2021 rat study used a focal middle cerebral artery occlusion (MCAO) model to evaluate DSIP administered intranasally at 120 µg/kg in Sprague-Dawley rats, assessing motor performance and infarct volume.
Epitalon
Epitalon (AEDG) is a synthetic tetrapeptide comprising the sequence Ala-Glu-Asp-Gly, joined through α-peptide bonds, originally derived from the amino acid composition of Epithalamin, a bovine pineal gland extract, and subsequently detected in physiological pineal gland tissue.
Over approximately 25 years, Epitalon has been examined across in vitro, in vivo, and in silico experimental frameworks. In vitro studies have employed a broad range of cell types including human fetal fibroblasts, HeLa cells, lymphocytes, thymocytes, neuroblastoma cells, pinealocytes, oocytes, and mesenchymal stem cells. Animal models have encompassed multiple rodent strains (Wistar and Sprague-Dawley rats; CBA, SHR, and HER-2/neu transgenic mice), Drosophila melanogaster, Rhesus monkeys, and Xenopus laevis, among others. A limited number of clinical investigations have also been conducted, including a study of 162 patients with retinitis pigmentosa and a study of 75 women examining circadian-related endpoints.
This stack is sold strictly for in-vitro and laboratory research purposes only.