Anti-Aging Stack
The Anti-Aging Stack groups Epitalon and GHK-Cu, two peptides studied within aging-related research from complementary angles.
Why these compounds are studied together
Each compound is investigated along a different axis of the aging literature. Epitalon (Epithalon), a synthetic tetrapeptide based on the pineal peptide epithalamin, has been studied in the context of telomere biology and neuroendocrine and circadian regulation. GHK-Cu, a copper-binding tripeptide, has been studied for its influence on extracellular-matrix proteins such as collagen and elastin, on wound healing, and on broad gene-expression programs. They are grouped here because they approach aging research from distinct but related directions — Epitalon at the cellular and neuroendocrine level, GHK-Cu at the level of tissue and matrix remodeling.
Individual research backgrounds
Epitalon
Epitalon (AEDG) is a synthetic tetrapeptide comprising the sequence Ala-Glu-Asp-Gly, joined through α-peptide bonds, originally derived from the amino acid composition of Epithalamin, a bovine pineal gland extract, and subsequently detected in physiological pineal gland tissue.
Over approximately 25 years, Epitalon has been examined across in vitro, in vivo, and in silico experimental frameworks. In vitro studies have employed a broad range of cell types including human fetal fibroblasts, HeLa cells, lymphocytes, thymocytes, neuroblastoma cells, pinealocytes, oocytes, and mesenchymal stem cells. Animal models have encompassed multiple rodent strains (Wistar and Sprague-Dawley rats; CBA, SHR, and HER-2/neu transgenic mice), Drosophila melanogaster, Rhesus monkeys, and Xenopus laevis, among others. A limited number of clinical investigations have also been conducted, including a study of 162 patients with retinitis pigmentosa and a study of 75 women examining circadian-related endpoints.
GHK-Cu
GHK-Cu is a copper(II) coordination complex of the human tripeptide glycyl-L-histidyl-L-lysine, in which the Cu(II) ion is coordinated by the imidazole side-chain nitrogen of histidine, the alpha-amino nitrogen of glycine, and the deprotonated amide nitrogen of the peptide bond, conferring a copper(II) affinity comparable to the copper-transport site on albumin.
GHK-Cu has been investigated across a range of in vitro systems, including cultured human dermal fibroblasts, lung fibroblasts derived from COPD patients, keratinocyte-containing skin equivalents, mesenchymal stromal cells, and several human cancer cell lines. In vivo studies have employed subcutaneous wound-chamber implant models in rats, as well as wound-healing paradigms in rabbits, mice, pigs, and dogs. A limited number of placebo-controlled clinical studies in human subjects have also been conducted, including trials examining skin biopsy endpoints via immunohistological analysis. Additionally, genome-wide gene-expression profiling has been applied to characterize the compound's influence on large-scale transcriptional programs across multiple tissue types.
This stack is sold strictly for in-vitro and laboratory research purposes only.