Semax (10mg)

A single-component research material supplied for controlled research environments. Suitable for studies involving peptide characterization and method development in model systems.

Composition

• Semax: 10 mg

• Appearance: lyophilized powder in a sealed research vial

Research Focus (non-clinical)

• Peptide identity and purity assessment

• Assay development and calibration for quantitative analysis

• Chromatographic method optimization for impurity profiling and peak resolution

• Stability characterization of a lyophilized peptide under laboratory storage conditions

Documentation

• Lot-specific COA available

• Batch and lot traceability

Important Notice

• For research use only

• Not for human consumption

• Not intended to diagnose, treat, cure, or prevent any disease

Quality & Manufacturing

• Lot-specific COA

• Lyophilized for transit stability; batch traceable

• Tamper-evident seal; lot & test date on each vial

• No MOQ for online orders

• Bulk orders for physical locations start at 25-unit minimum

What It Is

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of the ACTH(4-10) fragment of adrenocorticotropic hormone, in which the endogenous ACTH(4-7) tetrapeptide sequence is C-terminally extended with the tripeptide Pro-Gly-Pro to confer resistance to peptidase degradation.

Research Background

Semax has been examined across a range of preclinical models, including rodent in vivo models of incomplete global cerebral ischemia, transient middle cerebral artery occlusion (tMCAO) in rats, and in vitro neuroblastoma cell (SH-SY5Y) assays, as well as artificial membrane systems using large unilamellar vesicles. Transcriptomic investigations using genome-wide RNA-Seq analysis following rat tMCAO have profiled differential gene expression at 24 hours in Semax-treated versus vehicle-treated animals. Neurochemical studies in rodents have characterized the peptide's interactions with striatal monoamine systems via microdialysis and tissue measurements. Additional in vitro biophysical studies, employing thioflavin T fluorescence, differential scanning calorimetry, and Western blotting, have examined the peptide's interaction with copper-induced amyloid-beta aggregation in membrane models.

Observed Areas of Interest in Research

Investigators have examined Semax's modulation of the BDNF/trkB signaling axis in rat hippocampus; a single intranasal administration in rats was associated with measured increases in BDNF protein, trkB receptor phosphorylation, and the corresponding mRNAs. Neurochemical studies in rodents reported that Semax produced a progressive increase in extracellular 5-HIAA (a serotonin metabolite) in the striatum and potentiated amphetamine-induced dopamine release, suggesting modulatory interactions with serotoninergic and dopaminergic systems. At the transcriptomic level in rat ischemia-reperfusion models, differentially expressed genes in Semax-treated animals clustered into pathways associated with neuronal signaling (GPCR signaling, synaptic transmission) and immune regulation (innate immune system, cytokine signaling, neutrophil degranulation). In vitro biophysical studies have also investigated the peptide's capacity to form stable complexes with copper ions and the relationship of this chelation to modulation of amyloid-beta oligomerization kinetics and membrane disruption in lipid vesicle models.

Research Notes

Purity verified by third-party laboratory analysis (Certificate of Analysis available on request). Supplied strictly for in-vitro and laboratory research use only. Not for human consumption.

All information above is provided for research and educational reference only and summarizes findings from published scientific literature (predominantly in-vitro and animal models). It does not describe outcomes in humans. This product is not a drug, dietary supplement, or article intended for human or veterinary use.

All products from Blitz Health are manufactured using a lyophilization (freeze-drying) process. This method is designed to maintain product integrity and allows vials to remain stable during shipping for approximately 3–4 months.

Once a vial is reconstituted with bacteriostatic water, it should be stored in the refrigerator to help maintain stability. Under these conditions, reconstituted material is generally considered stable for up to 30 days.

Lyophilization is a dehydration technique in which compounds are frozen and then exposed to low pressure. This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure. This powder can be kept at room temperature until reconstitution.

Upon receipt, products should be stored away from heat and light. For short-term use, refrigeration at approximately 4°C (39°F) is suitable. For long-term storage (several months to years), vials may be placed in a freezer at approximately -80°C (-112°F). Freezing is the preferred method for preserving product stability over extended periods.

⚠️ Important Notice:
These products are intended for research use only. Not for human consumption.