CJC-1295 Without DAC (10mg)

A single-component research material supplied for controlled research environments. Suitable for studies exploring GHRH-receptor pathway characterization in model systems.

Composition

• CJC-1295 (Without DAC)
• Appearance: Lyophilized powder in a sealed research vial

Research Focus (non-clinical)

• Peptide identity and purity assessment via HPLC/LC-MS
• Assay development and calibration for quantitative analysis of GHRH-analog activity in in-vitro or ex-vivo models
• Chromatographic method optimization for impurity profiling and peak resolution
• Stability characterization of a lyophilized peptide under laboratory storage conditions

For qualified research professionals and institutional laboratories. Not for human use.

Documentation & Quality Assurance

Each lot is sourced through our verified global supply chain with emphasis on traceability and quality control. We work diligently to obtain and maintain third-party analytical reports (HPLC/LC-MS) and Certificates of Analysis for each batch, as part of our ongoing quality process. These documents are reviewed internally and displayed as they become available. Independent third-party testing is also performed on select lots to confirm identity, purity, and alignment with our internal specifications.

Important Notice

This product is intended for laboratory research use only. It is not intended for human or veterinary use, and must not be used for diagnostic, therapeutic, or clinical purposes.
This material is not a drug, medical device, or dietary supplement, and has not been evaluated by the U.S. Food and Drug Administration.

Quality & Manufacturing

All materials are sourced from carefully vetted domestic and international manufacturing partners who follow quality systems consistent with ISO and cGMP principles. Each supplier is reviewed for reliability, documentation integrity, and transparency in testing.

We require a verified purity of 99% or higher and perform independent third-party spot testing to confirm that select lots meet our internal standards for identity, purity, and composition. Where available, endotoxin testing results are included on Certificates of Analysis to verify laboratory purity; their inclusion is for research quality assessment only and does not imply suitability for human or veterinary use.

All research materials are sealed for integrity and packaged for stability during storage and transport from manufacturing through final delivery.

What It Is

CJC-1295 without DAC (also designated Mod-GRF(1-29) or modified GRF 1-29) is a synthetic, C-terminally amidated 29-amino-acid analogue of human growth hormone-releasing factor (hGRF 1-29), modified with stabilizing amino acid substitutions that distinguish it from the native sequence and from the albumin-conjugated (DAC) variant of CJC-1295.

Research Background

Research into GRF(1-29) analogues has been conducted primarily in rat pituitary cell cultures (in vitro) and in rodent in vivo models, with some limited human pharmacokinetic investigations. Animal research using GHRH-knockout mice (GHRHKO) examined how sustained GHRH-receptor signalling via a related long-acting analogue influenced pituitary somatotroph populations and body composition over a five-week dosing period. A separate clinical investigation enrolled eleven healthy adult male volunteers to profile serum proteomic changes following administration of a GHRH analogue of this class and to examine correlations with downstream IGF-1 responses.

Observed Areas of Interest in Research

Researchers have focused on the interaction of GRF(1-29) analogues with the GHRH receptor expressed on anterior pituitary somatotroph cells, through which native GHRH promotes GH synthesis and release; the substituted analogues have been studied for their capacity to engage this receptor with altered potency and metabolic stability relative to the native sequence. In the GHRHKO mouse model, treatment with a cognate long-acting GHRH analogue was associated with increased total pituitary RNA and GH mRNA, with immunohistochemical evidence interpreted as indicating somatotroph cell proliferation — findings studied in the context of the GH/IGF-1 axis. The downstream serum proteome, including apolipoprotein A1 and transthyretin, has also been examined in early-stage human research as a means of characterizing the systemic signalling context of GHRH-receptor activation.

Research Notes

Purity verified by third-party laboratory analysis (Certificate of Analysis available on request). Supplied strictly for in-vitro and laboratory research use only. Not for human consumption.

All information above is provided for research and educational reference only and summarizes findings from published scientific literature (predominantly in-vitro and animal models). It does not describe outcomes in humans. This product is not a drug, dietary supplement, or article intended for human or veterinary use.

All products from Blitz Health are manufactured using a lyophilization (freeze-drying) process. This method is designed to maintain product integrity and allows vials to remain stable during shipping for approximately 3–4 months.

Once a vial is reconstituted with bacteriostatic water, it should be stored in the refrigerator to help maintain stability. Under these conditions, reconstituted material is generally considered stable for up to 30 days.

Lyophilization is a dehydration technique in which compounds are frozen and then exposed to low pressure. This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure. This powder can be kept at room temperature until reconstitution.

Upon receipt, products should be stored away from heat and light. For short-term use, refrigeration at approximately 4°C (39°F) is suitable. For long-term storage (several months to years), vials may be placed in a freezer at approximately -80°C (-112°F). Freezing is the preferred method for preserving product stability over extended periods.

⚠️ Important Notice:
These products are intended for research use only. Not for human consumption.