PT-141 (10mg)

A single-component research material supplied for controlled research environments. Suitable for studies involving melanocortin receptor pathway characterization (e.g., MC3R/MC4R models) and method development in model systems.

Composition

• PT-141 (Bremelanotide)
• Appearance: Lyophilized powder in a sealed research vial

Research Focus (non-clinical)

• Peptide identity and purity assessment via HPLC/LC-MS
• Assay development and calibration for quantitative analysis of melanocortin-receptor models
• Chromatographic method optimization for impurity profiling and peak resolution
• Stability characterization of a lyophilized peptide under laboratory storage conditions

For qualified research professionals and institutional laboratories. Not for human use.

Documentation & Quality Assurance

Each lot is sourced through our verified global supply chain with emphasis on traceability and quality control. We work diligently to obtain and maintain third-party analytical reports (HPLC/LC-MS) and Certificates of Analysis for each batch, as part of our ongoing quality process. These documents are reviewed internally and displayed as they become available. Independent third-party testing is also performed on select lots to confirm identity, purity, and alignment with our internal specifications.

Important Notice

This product is intended for laboratory research use only. It is not intended for human or veterinary use, and must not be used for diagnostic, therapeutic, or clinical purposes.
This material is not a drug, medical device, or dietary supplement, and has not been evaluated by the U.S. Food and Drug Administration.

Quality & Manufacturing

All materials are sourced from carefully vetted domestic and international manufacturing partners who follow quality systems consistent with ISO and cGMP principles. Each supplier is reviewed for reliability, documentation integrity, and transparency in testing.

We require a verified purity of 99% or higher and perform independent third-party spot testing to confirm that select lots meet our internal standards for identity, purity, and composition. Where available, endotoxin testing results are included on Certificates of Analysis to verify laboratory purity; their inclusion is for research quality assessment only and does not imply suitability for human or veterinary use.

All research materials are sealed for integrity and packaged for stability during storage and transport from manufacturing through final delivery.

What It Is

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (alpha-MSH) that functions as an agonist at melanocortin receptors, including MC3R and MC4R, and is the active metabolite of Melanotan II.

Research Background

PT-141 has been examined in preclinical models including rats and nonhuman primates, as well as in early-phase clinical studies in human male subjects, where pharmacokinetic and erectile-response endpoints were measured by RigiScan methodology. A separate line of preclinical investigation utilized female Syrian hamsters (Mesocricetus auratus) to study melanocortin receptor mRNA expression and conditioned place preference behavior. Early clinical studies evaluated intranasal administration, with dose-dependent pharmacokinetic parameters (Cmax, AUC, Tmax, and half-life) characterized across dose cohorts.

Observed Areas of Interest in Research

Researchers have examined PT-141's agonist activity at MC3R and MC4R, both of which are expressed primarily in the central nervous system; systemic administration in rat models produced increases in c-Fos immunoreactivity in hypothalamic neurons, indicating central neural pathway engagement. Studies in rats have additionally traced neural circuitry by demonstrating that neurons in the hypothalamic region take up pseudorabies virus injected into the corpus cavernosum, suggesting a neuroanatomical connection under investigation. In female Syrian hamster models, investigators characterized MC3R and MC4R mRNA distribution within the mesolimbic dopamine system — including the ventral tegmental area and nucleus accumbens — and assessed whether the compound altered receptor expression or conditioned reward behavior in that circuit. The broader pharmacological literature on MC4R, a family A G-protein coupled receptor, identifies this receptor's involvement in cAMP-mediated signaling and its studied roles in energy homeostasis, cardiovascular function, and reproductive physiology, providing the mechanistic context within which PT-141's receptor interactions have been investigated.

Research Notes

Purity verified by third-party laboratory analysis (Certificate of Analysis available on request). Supplied strictly for in-vitro and laboratory research use only. Not for human consumption.

All information above is provided for research and educational reference only and summarizes findings from published scientific literature (predominantly in-vitro and animal models). It does not describe outcomes in humans. This product is not a drug, dietary supplement, or article intended for human or veterinary use.

All products from Blitz Health are manufactured using a lyophilization (freeze-drying) process. This method is designed to maintain product integrity and allows vials to remain stable during shipping for approximately 3–4 months.

Once a vial is reconstituted with bacteriostatic water, it should be stored in the refrigerator to help maintain stability. Under these conditions, reconstituted material is generally considered stable for up to 30 days.

Lyophilization is a dehydration technique in which compounds are frozen and then exposed to low pressure. This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure. This powder can be kept at room temperature until reconstitution.

Upon receipt, products should be stored away from heat and light. For short-term use, refrigeration at approximately 4°C (39°F) is suitable. For long-term storage (several months to years), vials may be placed in a freezer at approximately -80°C (-112°F). Freezing is the preferred method for preserving product stability over extended periods.

⚠️ Important Notice:
These products are intended for research use only. Not for human consumption.